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KMID : 0624620170500100528
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BMB Reports
2017 Volume.50 No. 10 p.528 ~ p.533
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Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence
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Park Young-Ho
Kim Hyun-Sun
Lee Jong-Hee
Choi Seon-A
Kim Jin-Man
Oh Goo-Taeg
Kang Sang-Won
Kim Sun-Uk
Yu Dae-Yeul
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Abstract
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Peroxiredoxin I (Prx I) plays an important role as a reactive oxygen species (ROS) scavenger in protecting and maintaining cellular homeostasis; however, the underlying mechanisms are not well understood. Here, we identified a critical role of Prx I in protecting cells against ROS-mediated cellular senescence by suppression of p16INK4a expression. Compared to wild-type mouse embryonic fibroblasts (WT-MEFs), Prx I?/? MEFs exhibited senescence-associated phenotypes. Moreover, the aged Prx I?/? mice showed an increased number of cells with senescence associated-β-galactosidase (SA-β-gal) activity in a variety of tissues. Increased ROS levels and SA-β-gal activity, and reduction of chemical antioxidant in Prx I?/? MEF further supported an essential role of Prx I peroxidase activity in cellular senescence that is mediated by oxidative stress. The up-regulation of p16INK4a expression in Prx I?/? and suppression by overexpression of Prx I indicate that Prx I possibly modulate cellular senescence through ROS/p16INK4a pathway.
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KEYWORD
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Antioxidant enzyme, Cellular senescence, Oxidative stress, p16INK4a, Peroxiredoxin
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